Hyperthyroidism Adrenaline: Uncovering the Connection between Thyroid Hormone Excess and Myocardial β-Adrenergic Expression

Thyroid hormone excess, also known as hyperthyroidism, is a condition characterized by an overactive thyroid gland. This excessive production of thyroid hormones can lead to various cardiovascular manifestations that are similar to those produced by sympathoadrenal stimulation. In fact, studies have shown that the responses of left ventricular isovolumic contraction and relaxation during graded dobutamine infusion are significantly altered in individuals with hyperthyroidism.

One of the key findings in a recent study on the effects of thyroid hormone excess on myocardial β-adrenergic expression and responsiveness to infused agonists in the primate heart was that the increase in resting dP/dt max (a measure of cardiac contractility) and the decrease in τ (a measure of cardiac relaxation time) were both significant at each dobutamine dose. This suggests that hyperthyroidism can lead to an increase in myocardial β-adrenergic expression, which may contribute to the development of cardiovascular complications.

Furthermore, the study found that when expressed as a percent change, the response to β 2-adrenerg

Hyperthyroidism adrenaline